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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9399 | Menin-MLL inhibitor 20 | Epigenetic Reader Domain , Histone Methyltransferase | |
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities. | |||
T2649 | Menin-MLL inhibitor MI-2 | Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase |
Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. | |||
T2643 | MI-3 | Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase |
MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM). | |||
T12002 | Menin-MLL inhibitor 4 | Others | |
Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction . | |||
T79737 | Menin-MLL inhibitor 29 | Epigenetic Reader Domain | |
Menin-MLL Inhibitor 29 (Compound C1) is a Menin-MLL protein-protein interaction (PPI) inhibitor that demonstrates high affinity to Menin with a dissociation constant (K D) of 138 nM and impedes Menin's interaction with M... | |||
T12943 | SNDX-5613 | Epigenetic Reader Domain , Histone Methyltransferase | |
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias. | |||
T13336 | VTP50469 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase | |
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity. | |||
T72360 | Menin-MLL inhibitor 26 | ||
Menin-MLL inhibitor 26 is a Menin-MLL inhibitor. Menin-MLL inhibitor 26 also is an active reference. Menin-MLL inhibitor 26 can inhibits cell growth. Menin-MLL inhibitor 26 can be used for the research of leukemia . | |||
T79117 | Menin-MLL inhibitor 27 | Epigenetic Reader Domain | |
Menin-MLL inhibitor 27 effectively inhibits the interaction between Menin and MLL, serving as a potential tool in cancer research, particularly for acute myeloid leukemia (AML) [1]. | |||
T78151 | Bleximenib oxalate | Menin-MLL inhibitor 24 oxalate | Epigenetic Reader Domain |
Menin-MLL Inhibitor 24 (compound A) oxalate, a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, is utilized in cancer research [1]. | |||
T72135 | (1s,4s)-Menin-MLL inhibitor-23 | ||
(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1]. | |||
T28036 | MI-2-2 | MI22,MI 2 2 | Histone Methyltransferase |
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. | |||
T69628 | Iptacopan hydrochloride hydrate | ||
Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor. | |||
TQ0069 | MI-503 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction. | |||
T11925 | M‑89 | Epigenetic Reader Domain , Histone Methyltransferase | |
M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin binding. This compound holds potential for treating MLL leukemia... | |||
T16072 | MI-538 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). | |||
TQ0058 | MI-463 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). | |||
T22978 | MI-2 (hydrochloride) | Others | |
MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM). | |||
T24484 | ML399 | VU-0516340,VU 0516340,ML-399,VU0516340,ML 399 | |
ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action. | |||
T15831 | M-525 | Others | |
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, ir... |